CALL FOR PAPERS Pathophysiology of Hypertension Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension
نویسندگان
چکیده
Nancy L. Sehgel,* Yi Zhu,* Zhe Sun, Jerome P. Trzeciakowski, Zhongkui Hong, William C. Hunter, Dorothy E. Vatner, Gerald A. Meininger, and Stephen F. Vatner Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey; and Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri; and Department of Medical Physiology, Texas A&M University, College Station, Texas
منابع مشابه
Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension.
Increased vascular stiffness is fundamental to hypertension, and its complications, including atherosclerosis, suggest that therapy should also be directed at vascular stiffness, rather than just the regulation of peripheral vascular resistance. It is currently held that the underlying mechanisms of vascular stiffness in hypertension only involve the extracellular matrix and endothelium. We hyp...
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Hypertension and aging are both recognized to increase aortic stiffness, but their interactions are not completely understood. Most previous studies have attributed increased aortic stiffness to changes in extracellular matrix proteins that alter the mechanical properties of the vascular wall. Alternatively, we hypothesized that a significant component of increased vascular stiffness in hyperte...
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Arterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arterial stiffness results in earlier aortic pulse wave reflection leading to increased cardiac workloa...
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EFFECTS OF HYPERTENSION AND AGING ON VASCULAR SMOOTH MUSCLE CELL CONTRIBUTION TO RECONSTITUTED AORTIC TISSUE STIFFNESS by Nancy Lisa Sehgel Aortic stiffness increases with hypertension and aging, and much of this increase has been thought to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aor...
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AIMS Increased aortic stiffness is a fundamental manifestation of hypertension. However, the molecular mechanisms involved remain largely unknown. We tested the hypothesis that abnormal intrinsic vascular smooth muscle cell (VSMC) mechanical properties in large arteries, but not in distal arteries, contribute to the pathogenesis of aortic stiffening in hypertension, mediated by the serum respon...
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